975Exposure to Gastric Acid-Suppression Therapy is Associated with Healthcare-Associated and Community-Associated C. difficile Infection in Children
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چکیده
Healthcare-Associated and Community-Associated C. difficile Infection in Children Jennifer Jimenez; Marci Drees, MD, MS, FACP; Beth Loveridge-Lenza, MD; Stephen Eppes, MD; Fernando Delrosario, MD; Jersey Shore University Medical Center, Newark, NJ; Christiana Care Health System, Newark, DE; Jersey Shore University Medical Center, Neptune, NJ; Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE
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مروری بر مطالعات اپیدمیولوژیک عفونتهای ناشی از کلستریدیوم دیفیسیل
Clostridium difficile (C. difficile) is an important factor in the development of the gastrointestinal diseases because of irrational antibiotic prescription and antimicrobial resistance. In the past, this bacterium was introduced as an agent of the infection in the hospitals called "hospital acquired Clostridium difficile infection". This infection is a main cause of morbidity and mortality in...
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Introduction: Toxigenic Clostridium difficile is the major cause of antibiotic-associated diarrhea, colitis, and pseudomembranous colitis. The pathogenicity of C. difficile is related to toxins A&B. Children with cancer are at risk of developing C. difficile infection (CDI) due to increased exposure to antibiotics, immunosuppression, and longer hospital stays. Recently, due to higher sensitivity...
متن کاملIatrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infection.
BACKGROUND The incidence and severity of Clostridium difficile infections are increasing. Acid-suppressive therapy has been suggested as a risk factor for C difficile, but this remains controversial. METHODS We conducted a pharmacoepidemiologic cohort study, performing a secondary analysis of data collected prospectively on 101 796 discharges from a tertiary care medical center during a 5-yea...
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Clostridium difficile infection is a common cause of antibiotic-associated diarrhea. It causes no symptoms in more than one-half of infected patients, but can also cause a wide spectrum of illnesses and death. The incidence and severity have increased in recent years. The most important modifiable risk factor for C. difficile infection is antibiotic exposure; this risk is dose-related and highe...
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Results: A total of 665 nosocomial cases of C difficile colitis were identified. By unadjusted analysis, the risk of C difficile colitis significantly increased along with increasing intensity of acid-suppression (0.3% for no acidsuppression to 1.4% for maximal acid suppression). As expected, the risk of C difficile colitis also increased with antibiotic exposure. After adjusting for comorbid c...
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